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Medication dosages and concentrations when used in cats are often translated from use in other species, usually humans, dogs, rats and mice. Drugs are frequently not FDA approved for use in cats and they are considered off label when prescribed. Most cat owners would likely be surprised how many medications used to treat cats are off label. Drug company investment into acquiring FDA approval of drugs in cats is simply not cost effective. Therefore, determination of safety and efficacy of off-label use of drugs in cats is often reliant on studies such as this study by Sebbag at University of California at Davis and collaborators.
Famciclovir is a potent antiviral drug that is effective against many herpesviruses, including feline herpes virus 1 (FHV-1). FHV-1 is perhaps the most common cause of upper respiratory infections in cats. In most species, famciclovir is converted in vivo to penciclovir, the active antiviral metabolite. However, cats are obligate carnivores and have unique and often deficient metabolic pathways regarding drug absorption and metabolic conversion. In cats, famciclovir is variably absorbed and it is metabolized first to BRL42359 then to the active metabolite penciclovir. Penciclovir becomes saturated at increasing famciclovir doses and pharmokinetics is more complex than in other species.
Researchers performed a cross over study in 6 healthy male cats in which each of 3 doses of famciclovir (30, 40, or 90 mg/kg) was administered every 8 or 12 hours for 3 days. Plasma and tear samples were obtained at predetermined times after famciclovir administration. Pharmacokinetic parameters were then determined for BRL42359 and penciclovir by compartmental and noncompartmental methods. Conversion of BRL42359 to penciclovir was found to be a rate-limiting.
In conclusion, in order to acquire therapeutic levels of panciclovir in serum and tears, the researchers recommend dosage and dosage frequency of famciclovir 90 mg/kg every 12 hours for cats infected with feline herpes virus. (GO)
from Cat Health News from the Winn Feline Foundation http://ift.tt/2d3bM7C - Health News
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• This is real take it serious, i am JOHNSON JUDITH i am from Ireland. Who will believe that a herbal medicine can cure herpes, I never believe that this will work, i have spend a lot money getting drugs from the hospital to keep me and my son healthy, it got to a point that i was waiting for death to come because i was broke, one day i heard about this great man called Dr ODUWA who is well known for Herpes, HIV, and Cancer cure, i decided to email him I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared a herbal medicine (CURE) and, he gave my details to the Courier Office. they told me that 4-8 days I will receive the package and after receiving it, i took the medicine as prescribed by him at the end of the two weeks, he told me to go to the hospital for a checkup, and i went, surprisingly after the test the doctor confirm me Herpes simplex virus negative, and my son and i thought it was a joke, i went to other hospital and was also negative, thank you for saving our life's, I promise I will always testify of your good works. If you are herpes simplex virus patient, contact him and I am sure you will get cured, contact him via: dr.oduwaspellhome@gmail.com or whatsapp him at +2348070685053.
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I have been suffering from (HERPES) disease for the last four years and had constant pain, especially in my mouth. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (HIV and Cancer) by this Man Dr OSO and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr OSO telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr OSO assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr OSO on drosohaberhome@gmail.com) or call him whatsapp +2348162084839
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sir i am indeed grateful for the help i will forever be great-full and of course-recommend you to the world and all my friends my friends!!!
Hello, everyone! I,m here to explore blogs and forum about wonderful and most safe cure for (Herpes Virus).I was positive to the deadly virus called herpes and i lost hope because i was out casted and rejected even by my closet friends.i searched on-line to know and enquirer about cure for Herpes and i read someone testimony on how he was cured from Herpes so i decided to contact the same herbalist because i know that nature has the power to heal everything.i contacted him to know how he can help me and he told me never to worry that he will heal me with the natural herbs from God!after 2 days of contacting him, he told me that the cure has been ready and he sent it to me via DHL and it got to me after 3 days!i used the med as he instructed me (MORNING and EVENING) and i was cured!its really like a dream but i am so happy!thats the reason i decided to also add more comment of Him so that more can be saved just like me!and if you need his help, you can email him on nativehealthclinic@gmail.com, or whatsapp +2348140073965 I,m neme amber and you can get in touch with me via nemeamber@gmail.com..Contact him for help at Herpes virus HIV/AIDS CANCER COPD BRAIN TUMOR All kind of virus and disease
DeleteI can’t believe this is really true I never believe there is cure to this hsv 2 because all the hospital have told me there is no cure to it, few months ago I saw this man email DR.AZIEGBE on internet from a testimony share by someone who he help with his herbal cure I contact his email and ask for his help also, that is how he inform me about the cure process and this man sent me a herbal medicine which I took according to the way he instructed for 2 week I can’t believe when I go for test my result come out negative i am so happy to share this to the world there is real cure to herpes you can also contact DR.AZIEGBE through his email now DRAZIEGBE1SPELLHOME@GMAIL.COM and also WhatsApp him +2349035465208. or my assistant text me +1 (601) 452-8622 or email: JAMESAVA0001@GMAIL.COM...
ReplyDeleteI have been suffering from (HERPES) disease for the last four years and had constant pain, especially in my mouth. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (HIV and Cancer) by this Man Dr OSO and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr OSO telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr OSO assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email Dr OSO on drosohaberhome@gmail.com) or call him whatsapp +2348162084839
ReplyDeletehttps://sites.google.com/view/drosohaberhome/
His blog page https://drosohaberhome.blogspot.com
sir i am indeed grateful for the help i will forever be great-full and of course-recommend you to the world and all my friends my friends!!!
Hello, everyone! I,m here to explore blogs and forum about wonderful and most safe cure for (Herpes Virus).I was positive to the deadly virus called herpes and i lost hope because i was out casted and rejected even by my closet friends.i searched on-line to know and enquirer about cure for Herpes and i read someone testimony on how he was cured from Herpes so i decided to contact the same herbalist because i know that nature has the power to heal everything.i contacted him to know how he can help me and he told me never to worry that he will heal me with the natural herbs from God!after 2 days of contacting him, he told me that the cure has been ready and he sent it to me via DHL and it got to me after 3 days!i used the med as he instructed me (MORNING and EVENING) and i was cured!its really like a dream but i am so happy!thats the reason i decided to also add more comment of Him so that more can be saved just like me!and if you need his help, you can email him on nativehealthclinic@gmail.com, or whatsapp +2348140073965 I,m neme amber and you can get in touch with me via nemeamber@gmail.com..Contact him for help at Herpes virus HIV/AIDS CANCER COPD BRAIN TUMOR All kind of virus and disease
ReplyDelete