People in the most rural areas are more likely to die from colon cancer even though they are less likely to get it in the first place - Health News

Patients who live in remote or very small rural communities are a bit more likely to show up at their doctor's office with late-stage colon cancer than other Americans, which could help explain why patients who live in these areas have such poor colorectal cancer outcomes, a new study says.

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The study, published in The Journal of Rural Health, looked at the relationship between late-stage colorectal cancer at diagnosis and county-level characteristics, including the level of rurality (how rura a place is, patient characteristics, and factors such as persistent poverty, low education, and low employment.

The study notes that cancer outcomes are often worse for rural patients, with various studies finding they have an 8 to 15 percent greater chance of dying from colon cancer.

"While rural communities overall have lower incidence of cancers compared to urban populations, they have higher cancer-related mortality rates," says the report. In other words, people in the most rural areas are more likely to die from colon cancer even though they are less likely to get it in the first place.

The researchers identified 132,777 patients in Kentucky and nine other states who had colorectal cancer in 2011-14. After placing patients in five rural-to-urban categories, the study found that the adjusted percentages of stage 4 colon-cancer patients by county geography were: metropolitan areas, 19.3%; micropolitan areas (with a city of 10,000 to 50,000) adjacent to a metro area, 20.4%; non-adjacent micropolitan areas, 19.2%; small rural places, 20.2%; and remote rural places, 22.7%.

"Patients living in remote, small counties were significantly more likely to present with stage 4 colorectal cancer than patients living in other counties," the study report says.

The data came from cancer registries in California, Connecticut, Georgia, Hawaii, Iowa, Kentucky, Louisiana, New Mexico, Utah and Washington. The registries included 352 rural and 235 urban counties, representing 18% and 20% of all rural and urban U.S. counties, respectively.

In addition to the rural-urban factor, the study found that younger patients, black patients and single or widowed patients were more likely to present with late-stage colorectal cancer. The researchers note that these findings are consistent with decades of data and suggest that little or no improvement has been made in addressing these disparities.

It also found that a lack of insurance was the most significant predictor of late-stage diagnosis, which was also consistent with other research.

"Patient medical insurance categories had the greatest effects on the rate of stage 4 colorectal cancer at diagnosis. The rate was highest among uninsured patients (28.6%) compared to patients with any type of Medicaid insurance (24.4%) and other insured patients (18.4%)."

There were also differences in the rate of stage 4 colorectal cancer diagnosis across states.

"Patients in Kentucky had the lowest adjusted rate (18.2%) of stage 4 diagnosis while New Mexico and Washington State had the highest rates (21.6% and 22.1% respectively)," says the report.

Kentucky leads the nation in colon cancer incidents, but is nationally recognized for getting its citizens screened for it. According to a University of Kentucky news release dated March 18,  the Kentucky Cancer Consortium received an award for its ongoing efforts to increase colorectal cancer screening rates. The release said that between 1999 and 2016 screening rates in Kentucky rose from 35% to 70%, improving more than any other state in the country and moving the state from a ranking of 49th to 17th.

In addition to a known lack of screening services in rural areas, "the high cost of colonoscopy, access to specialty referral networks, lack of transportation, and lower health literacy may all play a role in these findings," says the report.

The researchers point out several limitations to the study, noting that while the data allowed for a patients's urban/rural status to be determined at a county level, some patients may not have been designated appropriately especially in states out West which have very large counties. It also recognized that only 10 states were included in the study, representing about one-third of all cancer patients nationally.

The report also notes that this study is consistent with the findings of several others that look at the rural/urban relationship to late-stage colorectal diagnosis, but not with all of them. It says this could be related to the studies using  different geographic stratifications.

The American Cancer Society recommends colorectal screening for average risk individuals to begin at the age of 45, instead of 50. Those with a family history of colon or rectal cancer should check with their doctor about getting screened earlier. Colon cancer is 90 percent curable when detected early.


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Extra info if you need it.

1)metro: the county has a town/urban cluster with a population of at least 50,000 (UIC 1,2),
2) adjacent micropolitan: the county is geographically adjacent to a metro county with the largest town/urban cluster having a population of 10,000-49,999 (UIC 3-7),
3) nonadjacent micropolitan: the county’s largest town/urban cluster has a population of 10,000-49,999 but is not adjacent to a metro county (UIC 8),
4) small rural: counties that are adjacent to a micropolitan county and whose largest town/urban cluster has a population of less than 10,000 (UIC 9,10), and
5) remote small rural: counties that are not adjacent to a micropolitan county and whose largest town/urban cluster has a population of less than 10,000 (UIC 11,12).

Low employment if less than 65% of residents 25-64 were employed in 2008 to 2012
Low education if 20% or more lacked a high school diploma or equivalent in same time period
persistent poverty if 20% or more were poor as defined by the 1980 to 2000 decinnial census, ACS 2007-2011

The study adjusts for patient and socioeconomic county covariates and considers patients from different categories of rural settings.





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